All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-CD47 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD47. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD47 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of B-cell Malignancies.
CAR Construction : Fig.1 Affinity determination of Hu5F9-G4. Binding of Hu5F9-G4 to monomeric or dimeric CD47 was analyzed by surface plasmon resonance yielding the indicated traces and binding constants. Liu, J., Wang, L., Zhao, F., Tseng, S., Narayanan, C., Shura, L., ... & Majeti, R. (2015). Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential. PloS one, 10(9), e0137345. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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