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Anti-gp100 T cell receptor ((gp100)-2), pCDTCR1 (TCR-YC0498)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The PMEL17 TCR (TRAV21 TRBV7-3) and gp100 TCR (TRAV17 TRBV19) are both specific for the human HLA-A*0201 restricted YLE epitope (gp100 280–288, sequence YLEPGPVTA).

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Details

  • Target
  • gp100
  • Epitope
  • YLEAGPVTA
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Targeting Diseases
  • Melanoma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • gp100
  • Host Species
  • Human

Target

  • Introduction
  • Previous studies showed that gp100 encoded epitopes are recognized by tumor-infiltrating lymphocytes and circulating T-cells, associated with tumor regression in metastatic melanoma patients after adoptive therapy. Among these, the nonamer epitope gp100 280–288 (YLEPGPVTA) was originally shown to be recognized by HLA-A*0201⁺ tumor-infiltrating lymphocytes from melanoma patients and subsequently eluted from HLA-A*0201 molecules on melanoma cells.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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