gp100

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

Associated Disease
Anti-gp100 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-M552-2 T cell First GPA7 8kb Lentiviral VHH-CD28 Camelid Inquiry
CAR-T-1-M552-G T cell First GPA7 8kb Lentiviral VHH-FcεRIγ Camelid Inquiry
CAR-T-1-M552-Z T cell First GPA7 8kb Lentiviral VHH-CD3ζ Camelid Inquiry
CAR-T-2-M552-2G T cell Second GPA7 8kb Lentiviral VHH-CD28-FcεRIγ Camelid Inquiry
CAR-T-2-M552-2Z T cell Second GPA7 8kb Lentiviral VHH-CD28-CD3ζ Camelid Inquiry
CAR-T-2-M552-4G T cell Second GPA7 8kb Lentiviral VHH-CD4-FcεRIγ Camelid Inquiry
CAR-T-2-M552-4Z T cell Second GPA7 8kb Lentiviral VHH-CD4-CD3ζ Camelid Inquiry
CAR-T-2-M552-8Z T cell Second GPA7 8kb Lentiviral VHH-CD8-CD3ζ Camelid Inquiry
CAR-T-2-M552-BZ T cell Second GPA7 8kb Lentiviral VHH-41BB-CD3ζ Camelid Inquiry
CAR-T-2-M552-CZ T cell Second GPA7 8kb Lentiviral VHH-b2c-CD3ζ Camelid Inquiry
CAR-T-3-M552-2BZ T cell Third GPA7 8kb Lentiviral VHH-CD28-41BB-CD3ζ Camelid Inquiry
CAR-T-3-M552-2XZ T cell Third GPA7 8kb Lentiviral VHH-CD28-OX40-CD3ζ Camelid Inquiry
Anti-gp100 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C075Z Human G7 Human ~8kb Lentiviral WTWNRQLYPEWTEAQRLD Non-modified HLA-DR4 Inquiry
TCR-C076Z Human gp100 Human ~8kb Lentiviral YLEPGPVTA Non-modified HLA-A2 Inquiry
TCR-C077Z Human PMEL17 Human ~8kb Lentiviral YLEPGPVTA Non-modified HLA-A2 Inquiry
TCR-C078Z Human R6C12 Human ~8kb Lentiviral aa 209-217 Non-modified HLA-A*0201 Inquiry
TCR-C079Z Human R6C12 Murinized ~8kb Lentiviral aa 209-217 Murinized and Codon-optimized and Cysteine-modi?ed HLA-A*0201 Inquiry
TCR-C080Z Human gp100(154) Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-C081Z Human MPD Human ~8kb Lentiviral YLEPGPVTA Non-modified HLA-A*0201 Inquiry
TCR-C082Z Human 296 Human ~8kb Lentiviral YLEPGPVTA Non-modified HLA-A2 Inquiry
TCR-C083Z Human L2G2 Human ~8kb Lentiviral aa 209-217 Non-modified HLA-A*0201 Inquiry
TCR-L023 Human Mouse 6700-8070bp retroviral vector KTWGQYWQV Non-modified TCR HLA-A2 Inquiry
TCR-L023Z Human Mouse 8kb Lentiviral KTWGQYWQV Non-modified HLA-A2 Inquiry
TCR-L024 Human Human 6700-8070bp retroviral vector IMDQVPFSV Non-modified TCR HLA-A2 Inquiry
TCR-L024Z Human Human 8kb Lentiviral IMDQVPFSV Non-modified HLA-A2 Inquiry
TCR-L025 Human Murinized (from Human) 6700-8070bp retroviral vector IMDQVPFSV Murinized TCR HLA-A2 Inquiry
TCR-L025Z Human Murinized (from Human) 8kb Lentiviral IMDQVPFSV Murinized HLA-A2 Inquiry
TCR-L026 Human Murinized (from Human) 6700-8070bp retroviral vector IMDQVPFSV Murinized and Cysteine-modified TCR HLA-A2 Inquiry
TCR-L026Z Human Murinized (from Human) 8kb Lentiviral IMDQVPFSV Murinized and Cysteine-modified HLA-A2 Inquiry
TCR-L027 Human Human 6700-8070bp retroviral vector YLEPGPVTA Non-modified TCR HLA-A2 Inquiry
TCR-L027Z Human Human 8kb Lentiviral YLEPGPVTA Non-modified HLA-A2 Inquiry
TCR-L028 Human Mouse 6700-8070bp retroviral vector gp100[154-162] Non-modified TCR HLA-A2 Inquiry
TCR-L029 Human Human 3111bp retroviral vector YLEPGPVTA Affinity enhanced HLA-A2 Inquiry
TCR-L029Z Human Human 8kb Lentiviral YLEPGPVTA Affinity enhanced HLA-A2 Inquiry
TCR-L030 Human Human 3111bp retroviral vector YLEPGPVTA Cysteine-modified TCR HLA-A2 Inquiry
TCR-L030Z Human Human 8kb Lentiviral YLEPGPVTA Cysteine-modified HLA-A2 Inquiry
TCR-L031 Human Murinized (from Human) 6700-8070bp retroviral vector KTWGQYWQV Murinized TCR HLA-A*0201 Inquiry
TCR-L031Z Human Murinized (from Human) 8kb Lentiviral KTWGQYWQV Murinized HLA-A*0201 Inquiry
TCR-L261 Human gp100 Mouse ~8kb Lentiviral IMDQVPFSV Non-modified HLA-A2 Inquiry
TCR-L365 Human T2(1)C Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L366 Human Sp(0.01)A Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L367 Human T2(1)A Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L368 Human T2(1)B Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L369 Human T2(1)K Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L370 Human Sp(0.1)A10 Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L371 Human T2(1)J Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L372 Human T2(1)N Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L373 Human T2(1)H Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L374 Human T2(1)P Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L375 Human Sp(0.01)B Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L376 Human Sp(0.01)C Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L377 Human Sp(1) A Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L378 Human T2(1)G Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L379 Human T2(1)M Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L380 Human T2(1)O Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L381 Human T2(1)Q Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L382 Human T2(1)T Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L383 Human T2(1)Cpost Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L384 Human T2(0.01)A Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L385 Human Sp(0.01)K Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L386 Human Sp(0.01)D Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L387 Human T2(1)S Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L388 Human Sp(5)B Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L389 Human T2(1) U Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L390 Human T2(1) I Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L391 Human T2(1) L Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L392 Human T2(1) R Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
TCR-L393 Human Sp(1)B Mouse ~8kb Lentiviral KTWGQYWQV Non-modified HLA-A*0201 Inquiry
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