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Anti-INS T cell receptor ((1E6)-6), pCDTCR1 (TCR-YC0558)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

It was reported that the 1E6 human CD8+ T cell clone, which mediates the destruction of β cells through the recognition of a major, HLA-A*0201–restricted, preproinsulin signal peptide (ALWGPDPAAA 15–24), can recognize upwards of 1 million different peptides. CD8+ T cells that recognize HLA-A*0201–ALWGPDPAAA have been shown to populate insulitic lesions in patients with type 1 diabetes (T1D). The epitope is an altered peptide ligand selected for binding to the 1E6 TCR, which recognizes the natural ligand ALWGPDPAAA bound to HLA-A*0201.

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Details

  • Target
  • INS
  • Target Species
  • Human
  • Epitope
  • YLGGPDFPTI
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Targeting Diseases
  • Insulin-dependent diabetes mellitus
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 1E6
  • Host Species
  • Human

Target

  • Introduction
  • After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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