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Anti-LeY KIR CAR (XW-617) Vector (XS-1122-YF617)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-LeY KIR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human LeY. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv (XW-617) of anti-LeY antibody linked to KIR2DS2 TM & ICD and DAP12. The vector product was designed for the discovery and development of cellular therapy against Acute myeloid leukemia (AML). This KIR signaling is designed to prolong KIR-CAR T cells' efficacy period by coupling the receptor chains during activation and decoupling them during rest, avoiding T cell exhaustion even in challenging solid-tumor environments.

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Details

  • Target
  • LeY
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Acute myeloid leukemia (AML)
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-KIR2DS2 TM&ICD-2A-DAP12
  • Discription of Signaling Cassetes
  • The dual binding and signal chains are designed to come together to form a single receptor complex when bound to a tumor target. Dual chain signaling provides prolonged T cell activation even in challenging solid-tumor environments. KIR CAR combines the power of NK cell KIR receptors with the long-term durability of T cells, resulting in a long-lasting and powerful anti-cancer efficacy. KIR CAR-T cells maintained activation and potent cytotoxic activities in solid tumors compared with the CD28 and 4-1BB co-stimulated CD3-ζ -based traditional CAR T cells. The DAP12 signal functions as both activation and co-stimulation for T cells, circumventing the CD3-ζ pathway to allow prolonged KIR-CAR function.

Target

  • Clone
  • XW-617
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • Lewis Y
  • Synonyms
  • Lewis Y
  • Introduction
  • The Lewis Y (LeY) antigen is a carbohydrate antigen that is overexpressed on a variety of tumor cells, including MM cells. LeY expression is found in approximately 50% of MM cases. The antigen is related to the Lewis blood group antigen system, but not expressed on the red blood cell membrane. Overall, LeY has limited expression in normal cells and tissues, and no evidence of on-target, off-tumor toxicity was found with anti-LeY CAR-T cells in pre-clinical studies.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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