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Anti-Mesothelin (XP793) h(4-1BB-CD3ζ) CAR-iT Cells (XS-0722-ZP1526)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Many different strategies are being investigated to develop "off-the-shelf" CAR T-cell therapies. The cumbersome manufacturing process and high cost of autologous CAR T cells may prevent some patients from receiving the treatment. Using induced pluripotent stem cells (iPSCs) as a starting source for CAR T cells is an attractive approach.

Our CAR-iT cells are engineered by incorporating a second-generation CAR into iPSCs-derived T cells using lentiviral transduction technology. These CAR-iT cells are expected to lysis tumor cells in vitro and demonstrated anti-tumor function in vivo.

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Specifications

  • Species
  • Human
  • Host Cell Type
  • CAR-iT Cells
  • Mycoplasma Testing
  • The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
  • Shipping
  • Dry ice
  • Storage
  • Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). Once reconstituted, the cells may be used for up to five days if properly stored at 2°C - 8°C in the buffer provided.
  • Warnings
  • Avoid multiple freeze/thaw cycles
  • Research Use Only
  • Our CAR cells are for research use only, not for diagnostic or therapeutic use.
  • Quality Control
  • Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification).
  • Sterility Testing
  • All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
  • Virological Safety Testing
  • A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus saftey assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

CAR Design

  • Target
  • Mesothelin
  • Target Species
  • Human
  • scFv Clone
  • XP793
  • scFv Host Spcies
  • Mouse
  • CAR Construction
  • scFv-4-1BB-CD3ζ
  • CAR Signaling Cassetes
  • 4-1BB
    4-1BB (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. 4-1BB is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). 4-1BB modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. 4-1BB enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the 4-1BB endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And 4-1BB results in a brightly expressed, stable receptor as the transmembrane domain. Including 4-1BB costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • CAR Vector Name
  • pCDCAR1
  • CAR Vector length
  • ~8kb
  • CAR Vector Type
  • Lentiviral vector
  • CAR Generation
  • Second
  • Targeting Diseases
  • Multiple Myeloma

Customize Your CAR Products

Customize Your CAR Products
Cannot find the desired product? Don't worry, just try our online CAR and CAR cell customizing system, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.
CAR and CAR Cell Customizing System

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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