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Anti-MUC1 (C595) h(scFv-CD3ε) TRuC-Jurkat Cells (XS-0123-ZP955)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The T cell receptor fusion construct (TRuC) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunit can effectively reprogram an intact TCR complex to recognize tumor surface antigens. Unlike CAR, TRuC become a functional component of the TCR complex. TRuC-T cells kill tumor cells as potently as second-generation CAR-T cells, but at significant lower cytokine release and despite the absence of an extra co-stimulatory domain.

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Specifications

  • Species
  • Human
  • Host Cell Type
  • Jurkat Cells
  • Mycoplasma Testing
  • The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.
  • Shipping
  • Dry ice
  • Storage
  • Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). Once reconstituted, the cells may be used for up to five days if properly stored at 2°C - 8°C in the buffer provided.
  • Warnings
  • Avoid multiple freeze/thaw cycles
  • Research Use Only
  • The jurkat cells are for research use only, not for diagnostic or therapeutic use.
  • Quality Control
  • Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification).
  • Sterility Testing
  • All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
  • Virological Safety Testing
  • A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus saftey assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

CAR Design

  • Target
  • MUC1
  • Target Species
  • Human
  • scFv Clone
  • C595
  • scFv Host Spcies
  • Mouse
  • CAR Construction
  • scFv-CD3ε

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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