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TS-Fluc Anti-B7-H6 (NKp30) 28BBζ CAR (XS-0722-YF121)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human B7-H6 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • B7-H6
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Pancreatic carcinoma, Hepatocellular carcinoma, Prostate carcinoma
  • Generation
  • 3nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-Fluc-EF1a-scFv-CD28-41BB-CD3ζ

Target

  • Clone
  • NKp30
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1
  • Synonyms
  • Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1; B7 Homolog 6; B7-H6; B7H6; Putative Ig-Like Domain-Containing Protein DKFZp686O24166/DKFZp686I21167; Natural Cytotoxicity Triggering Receptor 3 Ligand 1; DKFZp686O24166;
  • Introduction
  • B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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