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TS-Fluc Anti-LeY (XW-620) BBζ CAR (XS-0822-YF8845)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Mouse LeY chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • LeY
  • Targeting Diseases
  • Advanced Cancer
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-Fluc-EF1a-scFv-41BB-CD3ζ

Target

  • Clone
  • XW-620
  • Host
  • Rat
  • Target Species
  • Mouse
  • Gene Name
  • Lewis Y
  • Synonyms
  • Lewis Y
  • Introduction
  • The Lewis Y (LeY) antigen is a carbohydrate antigen that is overexpressed on a variety of tumor cells, including MM cells. LeY expression is found in approximately 50% of MM cases. The antigen is related to the Lewis blood group antigen system, but not expressed on the red blood cell membrane. Overall, LeY has limited expression in normal cells and tissues, and no evidence of on-target, off-tumor toxicity was found with anti-LeY CAR-T cells in pre-clinical studies.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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