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TS-IL15 SA Anti-CD70 (XW-205) 28BBζ CAR (XS-0822-YF10717)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human CD70 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • CD70
  • Targeting Diseases
  • Pancreatic Cancer; Renal Cell Cancer; Breast Cancer; Ovarian Cancer; Melanoma
  • Generation
  • Third-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ

Target

  • Clone
  • XW-205
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • TNFSF7
  • Synonyms
  • CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L
  • Introduction
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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