Customized Cell Culture Media Process Development Service

Creative Biolabs is dedicated to enhancing product yield and maximizing quality for customers by focusing on the advancement and refinement of cell culture processes and tailored media solutions. We also offer comprehensive services such as technology transfer, process scale-up for production, post-clinical process development and characterization, support for IND declaration, and composition of CTD materials.

Culture Media Formulation Development Service

At Creative Biolabs, our team of expert scientists and researchers is dedicated to designing and customizing culture media tailored to specific cell lines and production goals. We employ a systematic approach, considering various factors such as:

• Cell type (CHO, BHK, hybridoma, HEK and other human cell lines)
• Nutrient requirements
• Growth factors
• pH
• Osmolality
• Supplementation strategies.

Through rigorous testing and optimization, we fine-tune the formulation to provide the ideal environment for cell growth, productivity, and product quality. By understanding the unique requirements of different cell lines, we can optimize media formulation for the development of custom cell culture media and custom feed supplements.

High Throughput Cell Culture Process Development Platform

To expedite the cell culture process and enhance productivity, we employ high throughput cell culture process development strategies. We are able to simultaneously screen multiple conditions and optimize the critical process parameters by utilizing advanced automation and parallelization techniques, such as:

• Miniaturized bioreactors through the ambr platform
• High throughput chromatographic screening capabilities
• Complementary analytics

Process Characterization & Scale-down Validation Studies

• Extensive reactor characterization studies: The ability to conduct comprehensive studies across all scales, from the smaller ambr250 bioreactor to the larger 2000L disposable bioreactor. This ensures a thorough understanding of the process dynamics and performance across different scales, enabling efficient scale-up and optimization.
• Qualification of scale-down models: The capability to validate and qualify scale-down models for various bioreactor systems. Scale-down models replicate the behavior and performance of larger bioreactors in smaller-scale setups.

Highlights

Applications

The customized cell culture media process development services offered by Creative Biolabs find applications across a broad range of biopharmaceutical research and development activities, including:

• Monoclonal antibody production
• Recombinant protein expression
• Vaccine development
• Cell and gene therapy manufacturing
• Biosimilar development
• Cell line engineering

In each of these applications, optimizing the cell culture media formulation and process parameters is critical for achieving high productivity, reproducibility, and product quality.

With our comprehensive services and scientific expertise, we are committed to supporting our clients in their journey towards successful biopharmaceutical production. Please feel free to contact us for more about our services.

For Research Use Only | Not For Clinical Use