Human Ovary Cell OVCAR-3

OVCAR-3 (NIH-OVCAR3) is a commonly utilized cell line for high-grade serous ovarian cancer (HGSOC) cell line. It was originally established in 1982 from the ascites of a patient with ovarian adenocarcinoma who was resistant to multiple drugs. This cell line is extensively used in research on biomarkers, drug sensitivity, and treatment strategies for ovarian cancer.

The OVCAR-3 cell line has been referenced in a large number of publications related to ovarian cancer research, serving as a critical resource for investigating chemotherapy responses, drug sensitivities, and the development of new therapeutic strategies. The OVCAR-3 cell line possesses several significant characteristics:

• Model for High-Grade Serous Ovarian Cancer (HGSOC): OVCAR-3 is widely recognized as a representative model for HGSOC, exhibiting biological features that closely resemble those of the actual disease.
• Adaptive Plasticity: In response to environmental stresses such as hypoxia and shear stress, OVCAR-3 cells demonstrate significant adaptive changes, including metabolic shifts and morphological remodeling.
• Drug Resistance: OVCAR-3 cells exhibit resistance to certain chemotherapeutic agents.

Moreover, the characteristics of the OVCAR-3 cell line align closely with the genomic and transcriptomic profiles of clinical HGSOC patients, particularly regarding alterations in DDR genes, making it a valuable model for studying treatment responses in ovarian cancer.

Fig.1 The repair status following DNA damage induction on OVCAR3 cells.¹

OVCAR-3-based Proliferation Assay

Investigating the effects of the compound on OVCAR-3 cell proliferation can reveal the biological mechanisms of ovarian cancer, including the interactions between the compound and specific signaling pathways and cellular processes. Creative Biolabs offers OVCAR-3-based proliferation assay services for your target compounds. We also provide a variety of cell proliferation assay services with different cell types. We hope you can contact us, and let us help you make the most suitable choice.

Reference

1. Bradbury, A., et al. " Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting." Cancers 12.7 (2020): 1939. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use