Creative Biolabs stands at the forefront of ion channel screening services, offering clients unparalleled expertise and state-of-the-art technology. Our sodium ion channel assay service is specifically tailored to provide comprehensive and precise analysis, supporting drug discovery and development in a wide array of therapeutic areas.

Sodium Ion Channels

Sodium ion channels are integral membrane proteins that form ion channels, conducting sodium ions through a cell's plasma membrane. These channels play a crucial role in the generation and propagation of electrical signals in excitable cells, such as neurons and muscle cells. By allowing the selective passage of sodium ions, these channels facilitate rapid depolarization, which is essential for initiating action potentials. This process is fundamental in various physiological functions, including nerve impulse transmission, cardiac rhythm regulation, and muscle contraction. Sodium ion channels are highly selective and tightly regulated, and their malfunction is associated with numerous diseases, such as epilepsy, cardiac arrhythmias, and certain types of paralysis, making them important targets for therapeutic drugs.

Fig.1 Structure of sodium channels.¹

Comprehensive Screening Capabilities

At Creative Biolabs, we offer high-quality sodium ion channel screening services designed to accelerate drug discovery and development. Our advanced research platforms—including automated patch clamp, manual patch clamp studies, and fluorescence-based imaging—are equipped to handle a wide range of ion channel-related studies. Whether you are screening large compound libraries or investigating the mechanism of drug action for potential lead candidates, our services provide the insights you need to move forward in your research. With extensive experience in electrophysiology and drug screening, our team delivers reliable and accurate results to support your therapeutic development goals.

Understanding the unique requirements of each research project, Creative Biolabs offers customized assay development tailored to specific sodium ion channel targets. This involves the optimization of assay conditions, selection of appropriate cell lines, and implementation of predictive models to ensure the assay aligns accurately with the client's objectives.

Advantages

• Broad Sodium Channel Coverage
  We provide assays targeting a comprehensive range of sodium ion channels, including NaV1.1–NaV1.8 and late Na currents, enabling detailed profiling across neurological, muscular, and cardiac applications.
• Versatile Technology Platform
  Our services integrate automated patch clamp, manual patch clamp, and fluorescence-based imaging, offering high-throughput screening with precision and flexibility to suit diverse research goals.
• Custom Assay Development
  Creative Biolabs tailors assay conditions, cell lines, and predictive models to specific project needs, ensuring that results are accurate, relevant, and aligned with your therapeutic objectives.
• Mechanism & Safety Insights
  Our assays support drug screening, lead optimization, and in-depth mechanism-of-action and safety pharmacology studies, accelerating the development of effective and safe sodium channel-targeted therapies.

Applications of Our Service in Drug Development

• Drug Screening and Lead Optimization: We assist in the high-throughput screening of extensive compound libraries to identify potential drug candidates that target sodium ion channels, facilitating the lead optimization process.
• Mechanism of Action Studies: Understanding how potential drug candidates interact with sodium ion channels is critical. Our assays provide detailed insights into drug-channel interactions, aiding in the elucidation of their mechanism of action.
• Safety Pharmacology: Our services can be used to evaluate the safety and efficacy of drug candidates by assessing their effects on sodium ion channels, thus supporting the development of safe therapeutic agents.

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Reference

1. Zhang, Shuzhang, et al. "Ion channels in epilepsy: Blasting fuse for neuronal hyperexcitability." Epilepsy-advances in diagnosis and therapy (2019): 1-12. Distributed under Open Access license CC BY 3.0, without modification.

For Research Use Only | Not For Clinical Use