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Datasheets
| Specifications | |
|---|---|
| Product Description | 290-R is a selective small-molecule inhibitor of SGK3 that binds to the ATP-binding pocket of the kinase domain. It exhibits potent target engagement and serves as a valuable warhead for constructing bifunctional chemical agents to drive proteasomal clearance of SGK3. |
| Molecular Formula | C24H25ClN6O5S |
| Molecular Weight (Da) | 545.0 |
| Chemical Name | 2-chloro-5-methoxy-N-[4-[3-methyl-4-[[(2R)-morpholin-2-yl]methoxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | SGK3 |
| Alternative Names | CISK, SGK2, SGKL |
| Introduction | SGK3 is a serine-threonine kinase downstream of the PI3K signaling cascade, sharing high sequence homology with other SGK family members. It harbors a conserved kinase domain and a PX domain that mediates endosomal localization, driving phosphorylation of diverse cellular substrates to support cell survival and proliferation. |
| Gene ID | 23678 |
| UniProt ID | Q96BR1 |
| Related Disease | Breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma |
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