ProDeg™ 308-R, Target protein ligand (Protein Degrader) (CAT#: PRLG-003)
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Datasheets
| Specifications |
|---|
| Product Description |
308-R is a potent SGK3 inhibitor that occupies the kinase active site with high affinity. Its favorable binding properties make it suitable as a targeting ligand for developing bifunctional molecules that mediate proximity-induced degradation of SGK3. |
| Molecular Formula |
C23H23FN6O4S |
| Molecular Weight (Da) |
498.5 |
| Chemical Name |
2-fluoro-5-methyl-N-[4-[4-[[(2R)-morpholin-2-yl]methoxy]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]benzenesulfonamide |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
SGK3 |
| Alternative Names |
CISK, SGK2, SGKL |
| Introduction |
SGK3 is a serine-threonine kinase downstream of the PI3K signaling cascade, sharing high sequence homology with other SGK family members. It harbors a conserved kinase domain and a PX domain that mediates endosomal localization, driving phosphorylation of diverse cellular substrates to support cell survival and proliferation. |
| Gene ID |
23678 |
| UniProt ID |
Q96BR1 |
| Related Disease |
Breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma |
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