Recombinant Human ABL1 protein, Fc Tag (CAT#: PRLP-073)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human ABL1 protein, Fc Tag |
| Alternative Names |
ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl |
| Gene Name |
ABL1 |
| Species |
Human |
| Introduction |
ABL1 is a non-receptor tyrosine kinase containing an SH3 domain, an SH2 domain, and a C-terminal kinase domain. It localizes to both the cytoplasm and nucleus, where it regulates cell proliferation, cytoskeletal dynamics, and DNA damage responses. |
| Function |
ABL1 drives oncogenic signaling through constitutive kinase activity in certain fusion variants. Its well-characterized ATP-binding pocket can be selectively engaged by bifunctional chemical agents, which redirect it toward proteasome-dependent degradation and thereby abrogate aberrant downstream proliferative signaling. |
| Related Disease |
Chronic myeloid leukemia, acute lymphoblastic leukemia, gastrointestinal stromal tumor |
| Gene ID |
25 |
| UniProt ID |
P00519 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
1130 |
| Molecular Weight (kDa) |
122.9 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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