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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human ABL1 protein, Fc Tag |
| Alternative Names | ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl |
| Gene Name | ABL1 |
| Species | Human |
| Introduction | ABL1 is a non-receptor tyrosine kinase containing an SH3 domain, an SH2 domain, and a C-terminal kinase domain. It localizes to both the cytoplasm and nucleus, where it regulates cell proliferation, cytoskeletal dynamics, and DNA damage responses. |
| Function | ABL1 drives oncogenic signaling through constitutive kinase activity in certain fusion variants. Its well-characterized ATP-binding pocket can be selectively engaged by bifunctional chemical agents, which redirect it toward proteasome-dependent degradation and thereby abrogate aberrant downstream proliferative signaling. |
| Related Disease | Chronic myeloid leukemia, acute lymphoblastic leukemia, gastrointestinal stromal tumor |
| Gene ID | 25 |
| UniProt ID | P00519 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 1130 |
| Molecular Weight (kDa) | 122.9 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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