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Datasheets
| Specifications | |
|---|---|
| Product Description | Apcin-A is a small-molecule inhibitor of CDC20 that binds to the WD40 substrate-binding domain, disrupting APC/C-CDC20 interaction. It serves as a targeting ligand for bifunctional chemical agents aimed at degrading CDC20 via the ubiquitin-proteasome pathway. |
| Molecular Formula | C10H14Cl3N5O2 |
| Molecular Weight (Da) | 342.6 |
| Chemical Name | 3-aminopropyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | CDC20 |
| Alternative Names | CDC20A, OOMD14, OZEMA14, bA276H19.3, p55CDC |
| Introduction | CDC20 is a cell cycle regulatory protein containing seven WD40 repeats that form a beta-propeller structure, serving as the substrate-recognition subunit of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. |
| Gene ID | 991 |
| UniProt ID | Q12834 |
| Related Disease | Breast cancer, colorectal cancer, ovarian cancer, various solid tumors |
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