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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human BIRC2 protein, Fc Tag |
| Alternative Names | API1; MIHB; HIAP2; IAP-2; RNF48; cIAP1; Hiap-2; c-IAP1 |
| Gene Name | BIRC2 |
| Species | Human |
| Introduction | Baculoviral IAP repeat-containing protein 2 (BIRC2, cIAP1) possesses three BIR domains, a caspase activation and recruitment domain (CARD), and a C-terminal RING domain. It associates with TNF receptor signaling complexes. |
| Function | BIRC2 (cIAP1) is a key member of the inhibitor of apoptosis family featuring potent E3 ligase activity. In proximity-enforced degradation workflows, BIRC2 recruitment often triggers rapid, catalytic multi-ubiquitination of the target. It is highly valued for its ability to clear neo-substrates at sub-nanomolar concentration thresholds. |
| Related Disease | Lymphoid malignancies, various epithelial tumors (somatic mutation) |
| Gene ID | 329 |
| UniProt ID | Q13490 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 618 |
| Molecular Weight (kDa) | 69.9 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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