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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human BIRC3 protein, Fc Tag |
| Alternative Names | AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2 |
| Gene Name | BIRC3 |
| Species | Human |
| Introduction | BIRC3 (cIAP2) is highly homologous to BIRC2, containing three BIR domains, a CARD, and a RING finger. Its expression is induced by NF-κB signaling. |
| Function | BIRC3 (cIAP2) operates as an efficient ubiquitinating engine involved in cell survival pathways. When utilized as the degrader core, BIRC3 presents distinct tissue-expression dynamics and structural binding kinetics, enabling developers to bypass resistance mechanisms associated with more commonly hijacked E3 systems like CRBN. |
| Related Disease | Lymphoid malignancies, multiple myeloma, various epithelial tumors (somatic mutation) |
| Gene ID | 330 |
| UniProt ID | Q13489 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 604 |
| Molecular Weight (kDa) | 68.4 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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