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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human BIRC5 protein, Fc Tag |
| Alternative Names | API4; EPR-1 |
| Gene Name | BIRC5 |
| Species | Human |
| Introduction | Survivin (BIRC5) is the smallest IAP family member, composed of a single BIR domain and a C-terminal α-helical coiled-coil region, but lacks a RING domain. It is highly expressed in fetal tissues and most human cancers. |
| Function | BIRC5 (Survivin) is a structurally unique member of the IAP family. Though naturally associated with cell division, its overexpression in malignant tissues makes it a highly strategic target or recruitment vehicle for localized, proximity-induced target destruction, minimizing off-target liabilities in healthy cells. |
| Related Disease | Lung adenocarcinoma, kidney renal clear cell carcinoma, HCC, HNSCC, and various cancers (overexpression, poor prognosis) |
| Gene ID | 332 |
| UniProt ID | O15392 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 142 |
| Molecular Weight (kDa) | 16.5 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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