Recombinant Human BIRC5 protein, Fc Tag (CAT#: PRLP-009)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human BIRC5 protein, Fc Tag |
| Alternative Names |
API4; EPR-1 |
| Gene Name |
BIRC5 |
| Species |
Human |
| Introduction |
Survivin (BIRC5) is the smallest IAP family member, composed of a single BIR domain and a C-terminal α-helical coiled-coil region, but lacks a RING domain. It is highly expressed in fetal tissues and most human cancers. |
| Function |
BIRC5 (Survivin) is a structurally unique member of the IAP family. Though naturally associated with cell division, its overexpression in malignant tissues makes it a highly strategic target or recruitment vehicle for localized, proximity-induced target destruction, minimizing off-target liabilities in healthy cells. |
| Related Disease |
Lung adenocarcinoma, kidney renal clear cell carcinoma, HCC, HNSCC, and various cancers (overexpression, poor prognosis) |
| Gene ID |
332 |
| UniProt ID |
O15392 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
142 |
| Molecular Weight (kDa) |
16.5 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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