Recombinant Human BTRC protein, Fc Tag (CAT#: PRLP-011)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human BTRC protein, Fc Tag |
| Alternative Names |
FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP |
| Gene Name |
BTRC |
| Species |
Human |
| Introduction |
β-TrCP1 (encoded by BTRC) is an F-box protein that serves as the substrate receptor of the SCF E3 ligase complex, featuring WD40 repeats that bind phosphodegron motifs (DSGXXS). |
| Function |
BTRC (β-TrCP) is an F-box protein that dictates substrate specificity for the SCFβ-TrCP E3 ligase complex. In chimeric degradation strategies, BTRC offers a programmable route to target destruction by mimicking natural phospho-degron motifs, translating precise signaling events into targeted proteasomal clearance of pathogenic proteins. |
| Related Disease |
Breast cancer, gastric cancer (deregulation) |
| Gene ID |
8945 |
| UniProt ID |
Q9Y297 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
605 |
| Molecular Weight (kDa) |
69 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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