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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human BTRC protein, Fc Tag |
| Alternative Names | FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP |
| Gene Name | BTRC |
| Species | Human |
| Introduction | β-TrCP1 (encoded by BTRC) is an F-box protein that serves as the substrate receptor of the SCF E3 ligase complex, featuring WD40 repeats that bind phosphodegron motifs (DSGXXS). |
| Function | BTRC (β-TrCP) is an F-box protein that dictates substrate specificity for the SCFβ-TrCP E3 ligase complex. In chimeric degradation strategies, BTRC offers a programmable route to target destruction by mimicking natural phospho-degron motifs, translating precise signaling events into targeted proteasomal clearance of pathogenic proteins. |
| Related Disease | Breast cancer, gastric cancer (deregulation) |
| Gene ID | 8945 |
| UniProt ID | Q9Y297 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 605 |
| Molecular Weight (kDa) | 69 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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