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Datasheets
| Specifications | |
|---|---|
| Product Description | Bicalutamide is a non-steroidal anti-androgen that binds to the ligand-binding domain of the androgen receptor, competitively inhibiting androgen action. It serves as a warhead for bifunctional molecules mediating AR degradation. |
| Molecular Formula | C18H14F4N2O4S |
| Molecular Weight (Da) | 430.4 |
| Chemical Name | N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | AR |
| Alternative Names | AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM |
| Introduction | AR is a nuclear receptor transcription factor containing an N-terminal transactivation domain, a central DNA-binding domain with two zinc fingers, and a C-terminal ligand-binding domain. Upon androgen binding, it translocates to the nucleus and regulates target gene expression. |
| Gene ID | 367 |
| UniProt ID | P10275 |
| Related Disease | Prostate cancer, androgen insensitivity syndrome, spinal bulbar muscular atrophy |
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