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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human CBL protein, Fc Tag |
| Alternative Names | CBL2; NSLL; C-CBL; RNF55; FRA11B |
| Gene Name | CBL |
| Species | Human |
| Introduction | Casitas B-lineage lymphoma (CBL) is a RING-type E3 ligase that contains a tyrosine kinase binding (TKB) domain, a linker helix region, and a RING finger. It is an adaptor protein as well as an E3 ligase. |
| Function | CBL (c-Cbl) is a prominent RING-type E3 ligase and adaptor molecule that orchestrates receptor tyrosine kinase ubiquitination. In proximity-enforced destruction strategies, CBL provides an optimized platform for clearing hyperactivated membrane receptors, translating tyrosine phosphorylation status into selective, proteasome-mediated degradation. |
| Related Disease | Acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML) (mutation) |
| Gene ID | 867 |
| UniProt ID | P22681 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 906 |
| Molecular Weight (kDa) | 120 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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