Recombinant Human CBL protein, Fc Tag (CAT#: PRLP-020)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human CBL protein, Fc Tag |
| Alternative Names |
CBL2; NSLL; C-CBL; RNF55; FRA11B |
| Gene Name |
CBL |
| Species |
Human |
| Introduction |
Casitas B-lineage lymphoma (CBL) is a RING-type E3 ligase that contains a tyrosine kinase binding (TKB) domain, a linker helix region, and a RING finger. It is an adaptor protein as well as an E3 ligase. |
| Function |
CBL (c-Cbl) is a prominent RING-type E3 ligase and adaptor molecule that orchestrates receptor tyrosine kinase ubiquitination. In proximity-enforced destruction strategies, CBL provides an optimized platform for clearing hyperactivated membrane receptors, translating tyrosine phosphorylation status into selective, proteasome-mediated degradation. |
| Related Disease |
Acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML) (mutation) |
| Gene ID |
867 |
| UniProt ID |
P22681 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
906 |
| Molecular Weight (kDa) |
120 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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