Recombinant Human CBLB protein, Fc Tag (CAT#: PRLP-021)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human CBLB protein, Fc Tag |
| Alternative Names |
Cbl-b; RNF56; ADMIO3; Nbla00127 |
| Gene Name |
CBLB |
| Species |
Human |
| Introduction |
CBL-B is a paralog of CBL with similar domain structure: TKB domain, linker, RING domain, and a large C-terminal proline-rich region. It is predominantly expressed in immune cells. |
| Function |
CBLB acts as a master negative regulator of immune cell activation via its E3 ligase activity. Utilizing CBLB within chimeric degradation configurations allows for a highly strategic dual-action therapeutic outcome: driving the destruction of a specific disease target while simultaneously stimulating local immune cell vigilance against tumors. |
| Related Disease |
Chronic myelogenous leukemia (CML), acute myeloid leukemia (AML) (mutation) |
| Gene ID |
868 |
| UniProt ID |
Q13191 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
982 |
| Molecular Weight (kDa) |
109 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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