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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human CBLB protein, Fc Tag |
| Alternative Names | Cbl-b; RNF56; ADMIO3; Nbla00127 |
| Gene Name | CBLB |
| Species | Human |
| Introduction | CBL-B is a paralog of CBL with similar domain structure: TKB domain, linker, RING domain, and a large C-terminal proline-rich region. It is predominantly expressed in immune cells. |
| Function | CBLB acts as a master negative regulator of immune cell activation via its E3 ligase activity. Utilizing CBLB within chimeric degradation configurations allows for a highly strategic dual-action therapeutic outcome: driving the destruction of a specific disease target while simultaneously stimulating local immune cell vigilance against tumors. |
| Related Disease | Chronic myelogenous leukemia (CML), acute myeloid leukemia (AML) (mutation) |
| Gene ID | 868 |
| UniProt ID | Q13191 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 982 |
| Molecular Weight (kDa) | 109 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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