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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human CDC20 protein, Fc Tag |
| Alternative Names | CDC20A, OOMD14, OZEMA14, bA276H19.3, p55CDC |
| Gene Name | CDC20 |
| Species | Human |
| Introduction | CDC20 is a cell cycle regulatory protein containing seven WD40 repeats that form a beta-propeller structure, serving as the substrate-recognition subunit of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. |
| Function | CDC20 activates APC/C to trigger the metaphase-anaphase transition by targeting securin and cyclin B for degradation. Its WD40 substrate-binding pocket can be engaged by bifunctional chemical agents to redirect its ubiquitin ligase activity, enabling proximity-induced degradation of neo-substrates while modulating mitotic progression. |
| Related Disease | Breast cancer, colorectal cancer, ovarian cancer, various solid tumors |
| Gene ID | 991 |
| UniProt ID | Q12834 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 499 |
| Molecular Weight (kDa) | 54.7 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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