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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human CRBN protein, Fc Tag |
| Alternative Names | MRT2; MRT2A |
| Gene Name | CRBN |
| Species | Human |
| Introduction | Cereblon (CRBN) is a substrate receptor of the CUL4-RBX1-DDB1 E3 ligase complex, featuring a Lon protease-like domain that binds thalidomide and its derivatives. |
| Function | CRBN (Cereblon) serves as the primary substrate receptor within the CRL4-CRBN complex. It holds a foundational status in structural chimerism due to its proven track record with small-molecule glues. It is extensively utilized to target intracellular proteins, offering high catalytic efficiency and versatile pocket adaptation for chemical recruitment without altering native DNA sequences. |
| Related Disease | Multiple myeloma, 5q- myelodysplastic syndrome, teratogenicity (thalidomide embryopathy) |
| Gene ID | 51185 |
| UniProt ID | Q96SW2 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 442 |
| Molecular Weight (kDa) | 51 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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