Recombinant Human CRBN protein, Fc Tag (CAT#: PRLP-003)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human CRBN protein, Fc Tag |
| Alternative Names |
MRT2; MRT2A |
| Gene Name |
CRBN |
| Species |
Human |
| Introduction |
Cereblon (CRBN) is a substrate receptor of the CUL4-RBX1-DDB1 E3 ligase complex, featuring a Lon protease-like domain that binds thalidomide and its derivatives. |
| Function |
CRBN (Cereblon) serves as the primary substrate receptor within the CRL4-CRBN complex. It holds a foundational status in structural chimerism due to its proven track record with small-molecule glues. It is extensively utilized to target intracellular proteins, offering high catalytic efficiency and versatile pocket adaptation for chemical recruitment without altering native DNA sequences. |
| Related Disease |
Multiple myeloma, 5q- myelodysplastic syndrome, teratogenicity (thalidomide embryopathy) |
| Gene ID |
51185 |
| UniProt ID |
Q96SW2 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
442 |
| Molecular Weight (kDa) |
51 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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