Recombinant Human EED protein, Fc Tag (CAT#: PRLP-072)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human EED protein, Fc Tag |
| Alternative Names |
COGIS, HEED, WAIT1 |
| Gene Name |
EED |
| Species |
Human |
| Introduction |
EED is a core component of the Polycomb repressive complex 2 (PRC2), containing seven WD40 repeats that form a beta-propeller scaffold. It binds to histone H3 methylated at lysine 27 and is essential for PRC2-mediated gene silencing. |
| Function |
EED is a structural scaffold protein that allosterically activates the EZH2 methyltransferase within PRC2, driving H3K27 trimethylation and epigenetic gene silencing. Its histone-binding pocket can be targeted by bifunctional molecules to induce proteasomal degradation, disrupting PRC2 assembly and reactivating silenced tumor suppressor genes. |
| Related Disease |
Diffuse large B-cell lymphoma, prostate cancer, breast cancer, pediatric glioma |
| Gene ID |
8726 |
| UniProt ID |
O75530 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
441 |
| Molecular Weight (kDa) |
50.2 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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