Please feel free to contact us for a quote and further discussion with our scientists.
Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human EED protein, Fc Tag |
| Alternative Names | COGIS, HEED, WAIT1 |
| Gene Name | EED |
| Species | Human |
| Introduction | EED is a core component of the Polycomb repressive complex 2 (PRC2), containing seven WD40 repeats that form a beta-propeller scaffold. It binds to histone H3 methylated at lysine 27 and is essential for PRC2-mediated gene silencing. |
| Function | EED is a structural scaffold protein that allosterically activates the EZH2 methyltransferase within PRC2, driving H3K27 trimethylation and epigenetic gene silencing. Its histone-binding pocket can be targeted by bifunctional molecules to induce proteasomal degradation, disrupting PRC2 assembly and reactivating silenced tumor suppressor genes. |
| Related Disease | Diffuse large B-cell lymphoma, prostate cancer, breast cancer, pediatric glioma |
| Gene ID | 8726 |
| UniProt ID | O75530 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 441 |
| Molecular Weight (kDa) | 50.2 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
