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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human FBXW11 protein, Fc Tag |
| Alternative Names | Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED |
| Gene Name | FBXW11 |
| Species | Human |
| Introduction | β-TrCP2 (encoded by FBXW11) is a paralog of β-TrCP1, with high sequence similarity and overlapping substrate recognition via WD40 domains that bind phosphodegrons. |
| Function | FBXW11 functions as an alternative F-box receptor within the SCF ubiquitin ligase network, sharing functional overlap with β-TrCP. Its role in targeted degradation revolves around its specific recognition of phosphorylated peptide fragments, offering a reliable, sequence-specific recruitment hub for chimeric molecules targeting structural oncoproteins. |
| Related Disease | Gastric cancer, breast cancer (mutation / in-frame insertion) |
| Gene ID | 23291 |
| UniProt ID | Q9UKB1 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 542 |
| Molecular Weight (kDa) | 58.2 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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