Recombinant Human FBXW11 protein, Fc Tag (CAT#: PRLP-012)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human FBXW11 protein, Fc Tag |
| Alternative Names |
Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED |
| Gene Name |
FBXW11 |
| Species |
Human |
| Introduction |
β-TrCP2 (encoded by FBXW11) is a paralog of β-TrCP1, with high sequence similarity and overlapping substrate recognition via WD40 domains that bind phosphodegrons. |
| Function |
FBXW11 functions as an alternative F-box receptor within the SCF ubiquitin ligase network, sharing functional overlap with β-TrCP. Its role in targeted degradation revolves around its specific recognition of phosphorylated peptide fragments, offering a reliable, sequence-specific recruitment hub for chimeric molecules targeting structural oncoproteins. |
| Related Disease |
Gastric cancer, breast cancer (mutation / in-frame insertion) |
| Gene ID |
23291 |
| UniProt ID |
Q9UKB1 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
542 |
| Molecular Weight (kDa) |
58.2 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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