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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human FBXW7 protein, Fc Tag |
| Alternative Names | B56E; B56epsilon |
| Gene Name | FBXW7 |
| Species | Human |
| Introduction | F-box and WD repeat domain-containing 7 (FBXW7) is the substrate recognition subunit of the SCF (SKP1-CUL1-F-box) E3 ligase complex. It contains multiple WD40 repeats that recognize phosphorylated degrons. |
| Function | FBXW7 is a critical substrate recognition component of the SCF (SKP1-CUL1-F-box) complex that natively targets key oncoproteins. Utilizing FBXW7 within proximity-induced paradigms enables highly selective, phosphorylation-dependent destruction of neo-substrates, exploiting its mature structural biology and precise WD40 repeat binding pocket. |
| Related Disease | Colorectal cancer, endometrial cancer, squamous cell carcinoma of head and neck, various cancers (mutation, tumor suppressor) |
| Gene ID | 55294 |
| UniProt ID | Q969H0 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 707 |
| Molecular Weight (kDa) | 79 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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