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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human FKBP1A protein, Fc Tag |
| Alternative Names | FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE |
| Gene Name | FKBP1A |
| Species | Human |
| Introduction | FKBP1A (FKBP12) is a peptidyl-prolyl cis-trans isomerase of the FKBP family, containing a single FKBP domain that binds the immunosuppressant FK506 and rapamycin. It catalyzes protein folding and regulates the activity of multiple signaling proteins. |
| Function | FKBP12 acts as a molecular chaperone and a regulatory subunit of several signaling complexes including mTOR and TGF-beta receptors. Its ligand-binding pocket can be selectively engaged by bifunctional chemical agents, which redirect it toward proximity-induced ubiquitination and proteasomal degradation of target proteins, modulating diverse cellular signaling networks. |
| Related Disease | Organ transplant rejection, autoimmune diseases, cancer, neurodegenerative disorders |
| Gene ID | 2280 |
| UniProt ID | P62942 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 108 |
| Molecular Weight (kDa) | 12 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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