ProDeg™ GNF-5, Target protein ligand (Protein Degrader) (CAT#: PRLG-005)
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Datasheets
| Specifications |
|---|
| Product Description |
GNF-5 is an allosteric inhibitor of BCR-ABL that binds to the myristoyl pocket of the kinase domain, stabilizing the inactive conformation. Its unique binding mode makes it a valuable warhead for bifunctional molecules targeting ABL1 for degradation. |
| Molecular Formula |
C20H17F3N4O3 |
| Molecular Weight (Da) |
418.4 |
| Chemical Name |
N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
ABL1 |
| Alternative Names |
ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl |
| Introduction |
ABL1 is a non-receptor tyrosine kinase containing an SH3 domain, an SH2 domain, and a C-terminal kinase domain. It localizes to both the cytoplasm and nucleus, where it regulates cell proliferation, cytoskeletal dynamics, and DNA damage responses. |
| Gene ID |
25 |
| UniProt ID |
P00519 |
| Related Disease |
Chronic myeloid leukemia, acute lymphoblastic leukemia, gastrointestinal stromal tumor |
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