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Datasheets
| Specifications | |
|---|---|
| Product Description | GNF-5 is an allosteric inhibitor of BCR-ABL that binds to the myristoyl pocket of the kinase domain, stabilizing the inactive conformation. Its unique binding mode makes it a valuable warhead for bifunctional molecules targeting ABL1 for degradation. |
| Molecular Formula | C20H17F3N4O3 |
| Molecular Weight (Da) | 418.4 |
| Chemical Name | N-(2-hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | ABL1 |
| Alternative Names | ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl |
| Introduction | ABL1 is a non-receptor tyrosine kinase containing an SH3 domain, an SH2 domain, and a C-terminal kinase domain. It localizes to both the cytoplasm and nucleus, where it regulates cell proliferation, cytoskeletal dynamics, and DNA damage responses. |
| Gene ID | 25 |
| UniProt ID | P00519 |
| Related Disease | Chronic myeloid leukemia, acute lymphoblastic leukemia, gastrointestinal stromal tumor |
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