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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human ITCH protein, Fc Tag |
| Alternative Names | AIF4; AIP4; ADMFD; NAPP1 |
| Gene Name | ITCH |
| Species | Human |
| Introduction | Itchy E3 ubiquitin ligase (ITCH) is a HECT domain ligase containing four WW domains (protein-protein interaction modules) that bind PPxY motifs in substrates. |
| Function | ITCH is a HECT-domain E3 ubiquitin ligase that controls key immune and apoptotic cascades. In proximity-induced target destruction, ITCH is highly valued for its modular WW domains, which can be precisely engaged by engineered peptide or small-molecule linkers to drive the catalytic polyubiquitination of refractory cytoplasmic proteins. |
| Related Disease | Syndromic multisystem autoimmune disease (ADMFD) (ITCH deficiency), systemic autoimmunity, immunodeficiency |
| Gene ID | 83737 |
| UniProt ID | Q96J02 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 903 |
| Molecular Weight (kDa) | 108 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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