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Datasheets
| Specifications | |
|---|---|
| Product Description | IY-IY-TEG is a peptide-based ligand targeting the TRKC receptor, derived from neurotrophin-3 binding epitopes. It serves as a targeting moiety for bifunctional molecules aimed at degrading TRK fusion proteins. |
| Molecular Formula | C52H74N16O7 |
| Molecular Weight (Da) | 1035.3 |
| Chemical Name | (2S)-2-[4-[(1S,2S)-1-amino-2-methylbutyl]triazol-1-yl]-1-[4-[4-[4-[(2S)-2-[4-[(1S,2S)-1-amino-2-methylbutyl]triazol-1-yl]-3-(4-hydroxyphenyl)propanoyl]piperazin-1-yl]-6-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethylamino]-1,3,5-triazin-2-yl]piperazin-1-yl]-3-(4-hydroxyphenyl)propan-1-one |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | NTRK3 |
| Alternative Names | GP145-TrkC, TRKC, gp145(trkC) |
| Introduction | NTRK3 (TRKC) is a receptor tyrosine kinase of the neurotrophin receptor family, containing two extracellular cysteine-rich clusters, a leucine-rich region, two immunoglobulin-like domains, and an intracellular kinase domain. It is activated by neurotrophin-3 (NT-3). |
| Gene ID | 4916 |
| UniProt ID | Q16288 |
| Related Disease | Secretory breast carcinoma, infantile fibrosarcoma, congenital mesoblastic nephroma, colorectal cancer |
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