ProDeg™ IY-IY-TEG, Target protein ligand (Protein Degrader) (CAT#: PRLG-011)
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Datasheets
| Specifications |
|---|
| Product Description |
IY-IY-TEG is a peptide-based ligand targeting the TRKC receptor, derived from neurotrophin-3 binding epitopes. It serves as a targeting moiety for bifunctional molecules aimed at degrading TRK fusion proteins. |
| Molecular Formula |
C52H74N16O7 |
| Molecular Weight (Da) |
1035.3 |
| Chemical Name |
(2S)-2-[4-[(1S,2S)-1-amino-2-methylbutyl]triazol-1-yl]-1-[4-[4-[4-[(2S)-2-[4-[(1S,2S)-1-amino-2-methylbutyl]triazol-1-yl]-3-(4-hydroxyphenyl)propanoyl]piperazin-1-yl]-6-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethylamino]-1,3,5-triazin-2-yl]piperazin-1-yl]-3-(4-hydroxyphenyl)propan-1-one |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
NTRK3 |
| Alternative Names |
GP145-TrkC, TRKC, gp145(trkC) |
| Introduction |
NTRK3 (TRKC) is a receptor tyrosine kinase of the neurotrophin receptor family, containing two extracellular cysteine-rich clusters, a leucine-rich region, two immunoglobulin-like domains, and an intracellular kinase domain. It is activated by neurotrophin-3 (NT-3). |
| Gene ID |
4916 |
| UniProt ID |
Q16288 |
| Related Disease |
Secretory breast carcinoma, infantile fibrosarcoma, congenital mesoblastic nephroma, colorectal cancer |
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