Recombinant Human KEAP1 protein, Fc Tag (CAT#: PRLP-013)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human KEAP1 protein, Fc Tag |
| Alternative Names |
INrf2; KLHL19 |
| Gene Name |
KEAP1 |
| Species |
Human |
| Introduction |
Kelch-like ECH-associated protein 1 (KEAP1) is a substrate adaptor for the CUL3-RBX1 E3 ligase complex. It contains a BTB domain for CUL3 binding and a double-glycine repeat (Kelch) domain for substrate recognition. |
| Function |
KEAP1 is a specialized BTB-Kelch substrate adaptor within the CRL3 complex that natively regulates oxidative stress responses. In targeted destruction systems, hijacking KEAP1 through its Kelch domain allows bifunctional molecules to tap into a highly responsive, tissue-specific degradation machinery, expanding the available E3 repertoire beyond ubiquitously expressed ligases. |
| Related Disease |
Non-small cell lung cancer (LUAD) (loss-of-function mutation → NRF2 hyperactivation, chemoresistance, poor prognosis) |
| Gene ID |
9817 |
| UniProt ID |
Q14145 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
624 |
| Molecular Weight (kDa) |
70 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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