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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human KEAP1 protein, Fc Tag |
| Alternative Names | INrf2; KLHL19 |
| Gene Name | KEAP1 |
| Species | Human |
| Introduction | Kelch-like ECH-associated protein 1 (KEAP1) is a substrate adaptor for the CUL3-RBX1 E3 ligase complex. It contains a BTB domain for CUL3 binding and a double-glycine repeat (Kelch) domain for substrate recognition. |
| Function | KEAP1 is a specialized BTB-Kelch substrate adaptor within the CRL3 complex that natively regulates oxidative stress responses. In targeted destruction systems, hijacking KEAP1 through its Kelch domain allows bifunctional molecules to tap into a highly responsive, tissue-specific degradation machinery, expanding the available E3 repertoire beyond ubiquitously expressed ligases. |
| Related Disease | Non-small cell lung cancer (LUAD) (loss-of-function mutation → NRF2 hyperactivation, chemoresistance, poor prognosis) |
| Gene ID | 9817 |
| UniProt ID | Q14145 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 624 |
| Molecular Weight (kDa) | 70 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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