Recombinant Human MDM2 protein, Fc Tag (CAT#: PRLP-004)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human MDM2 protein, Fc Tag |
| Alternative Names |
HDMX; LSKB; hdm2; ACTFS |
| Gene Name |
MDM2 |
| Species |
Human |
| Introduction |
Murine double minute 2 (MDM2) is an E3 ubiquitin ligase with an N-terminal p53-binding domain, a central acidic domain, and a C-terminal RING finger domain. It forms homodimers or heterodimers with MDM4. |
| Function |
MDM2 is a RING-domain E3 ligase that natively controls p53 tumor suppressor levels. In targeted degradation architectures, hijacking MDM2 offers a unique dual-mechanism advantage: it simultaneously induces the destruction of the pathogenic target protein and liberates active p53, triggering a synergistic apoptotic response in specialized cancer models. |
| Related Disease |
Well-differentiated/dedifferentiated liposarcoma, osteosarcoma, breast cancer, bladder cancer, and various other cancers (amplification) |
| Gene ID |
4193 |
| UniProt ID |
Q00987 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
491 |
| Molecular Weight (kDa) |
55 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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