Please feel free to contact us for a quote and further discussion with our scientists.
Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human MDM2 protein, Fc Tag |
| Alternative Names | HDMX; LSKB; hdm2; ACTFS |
| Gene Name | MDM2 |
| Species | Human |
| Introduction | Murine double minute 2 (MDM2) is an E3 ubiquitin ligase with an N-terminal p53-binding domain, a central acidic domain, and a C-terminal RING finger domain. It forms homodimers or heterodimers with MDM4. |
| Function | MDM2 is a RING-domain E3 ligase that natively controls p53 tumor suppressor levels. In targeted degradation architectures, hijacking MDM2 offers a unique dual-mechanism advantage: it simultaneously induces the destruction of the pathogenic target protein and liberates active p53, triggering a synergistic apoptotic response in specialized cancer models. |
| Related Disease | Well-differentiated/dedifferentiated liposarcoma, osteosarcoma, breast cancer, bladder cancer, and various other cancers (amplification) |
| Gene ID | 4193 |
| UniProt ID | Q00987 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 491 |
| Molecular Weight (kDa) | 55 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
