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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human MDM4 protein, Fc Tag |
| Alternative Names | HDMX; MDMX; MRP1; BMFS6 |
| Gene Name | MDM4 |
| Species | Human |
| Introduction | MDM4 (MDMX) is a structural homolog of MDM2 containing a p53-binding domain and a RING domain but lacking intrinsic E3 ligase activity. It forms stable heterodimers with MDM2 via the RING domain. |
| Function | MDM4 (MDMX) acts as a critical structural partner and regulator of MDM2. Its integration into proximity-induced degradation programs relies on its unique hydrophobic binding cleft, which can be selectively engaged by specialized bifunctional molecules to direct efficient, proteasome-mediated clearance of neo-substrates while modulating p53 signaling networks. |
| Related Disease | Various cancers with wild-type p53 (amplification) |
| Gene ID | 4194 |
| UniProt ID | O15151 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 490 |
| Molecular Weight (kDa) | 54 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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