ProDeg™ rapamycin, Target protein ligand (Protein Degrader) (CAT#: PRLG-006)
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Datasheets
| Specifications |
|---|
| Product Description |
Rapamycin is a macrocyclic natural product that binds to FKBP12 with high affinity, forming a complex that inhibits mTOR signaling. It is a classic warhead for bifunctional chemical agents, enabling recruitment of FKBP12 to drive degradation of neo-substrates. |
| Molecular Formula |
C51H79NO13 |
| Molecular Weight (Da) |
914.2 |
| Chemical Name |
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| Chemical Structure |
 |
| Purity |
0.99 |
| Size |
5 mg |
| Physical State |
Powder |
| Storage |
The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information |
|---|
| Target Name |
FKBP1A |
| Alternative Names |
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE |
| Introduction |
FKBP1A (FKBP12) is a peptidyl-prolyl cis-trans isomerase of the FKBP family, containing a single FKBP domain that binds the immunosuppressant FK506 and rapamycin. It catalyzes protein folding and regulates the activity of multiple signaling proteins. |
| Gene ID |
2280 |
| UniProt ID |
P62942 |
| Related Disease |
Organ transplant rejection, autoimmune diseases, cancer, neurodegenerative disorders |
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