Please feel free to contact us for a quote and further discussion with our scientists.
Datasheets
| Specifications | |
|---|---|
| Product Description | Rapamycin is a macrocyclic natural product that binds to FKBP12 with high affinity, forming a complex that inhibits mTOR signaling. It is a classic warhead for bifunctional chemical agents, enabling recruitment of FKBP12 to drive degradation of neo-substrates. |
| Molecular Formula | C51H79NO13 |
| Molecular Weight (Da) | 914.2 |
| Chemical Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| Chemical Structure |  |
| Purity | 0.99 |
| Size | 5 mg |
| Physical State | Powder |
| Storage | The power can be stored at 4 °C for 2 years or at -20 °C for 3 years. |
| Target Information | |
|---|---|
| Target Name | FKBP1A |
| Alternative Names | FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE |
| Introduction | FKBP1A (FKBP12) is a peptidyl-prolyl cis-trans isomerase of the FKBP family, containing a single FKBP domain that binds the immunosuppressant FK506 and rapamycin. It catalyzes protein folding and regulates the activity of multiple signaling proteins. |
| Gene ID | 2280 |
| UniProt ID | P62942 |
| Related Disease | Organ transplant rejection, autoimmune diseases, cancer, neurodegenerative disorders |
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
