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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human RNF31 protein, Fc Tag |
| Alternative Names | HOIP; Paul; ZIBRA; IMD115 |
| Gene Name | RNF31 |
| Species | Human |
| Introduction | RING finger protein 31 (RNF31, also HOIP) is the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), containing a RBR domain (RING1, IBR, RING2) that catalyzes linear (M1-linked) ubiquitination. |
| Function | RNF31 (HOIP) is the catalytic core of the Linear Ubiquitin Chain Assembly Complex (LUBAC). In targeted protein clearance, RNF31 recruitment introduces a non-canonical degradation pathway by generating linear ubiquitin chains on neo-substrates, altering their intracellular trafficking and marking them for proteasomal destruction. |
| Related Disease | Autoinflammatory syndrome, immunodeficiency, amylopectinosis, lymphangiectasia (LUBAC deficiency) |
| Gene ID | 55072 |
| UniProt ID | Q96EP0 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 1072 |
| Molecular Weight (kDa) | 120 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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