Recombinant Human RNF4 protein, Fc Tag (CAT#: PRLP-015)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human RNF4 protein, Fc Tag |
| Alternative Names |
SLX5; SNURF; RES4-26 |
| Gene Name |
RNF4 |
| Species |
Human |
| Introduction |
RING finger protein 4 (RNF4) is a small E3 ubiquitin ligase containing four SUMO-interacting motifs (SIMs) and a C-terminal RING domain. It recognizes poly-SUMOylated substrates. |
| Function |
RNF4 is a specialized small-molecule-responsive, SUMO-targeted ubiquitin ligase (STUbL). In proximity-induced therapeutics, RNF4 provides a unique mechanism by recognizing SUMOylated neo-substrates or being directly hijacked by covalent ligands, enabling the precise, signal-dependent clearance of stubborn macromolecular aggregates. |
| Related Disease |
Colon adenocarcinoma, breast cancer (elevated levels → poor survival), potentially tumor-promoting |
| Gene ID |
6047 |
| UniProt ID |
P78317 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
190 |
| Molecular Weight (kDa) |
23.7 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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