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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human RNF4 protein, Fc Tag |
| Alternative Names | SLX5; SNURF; RES4-26 |
| Gene Name | RNF4 |
| Species | Human |
| Introduction | RING finger protein 4 (RNF4) is a small E3 ubiquitin ligase containing four SUMO-interacting motifs (SIMs) and a C-terminal RING domain. It recognizes poly-SUMOylated substrates. |
| Function | RNF4 is a specialized small-molecule-responsive, SUMO-targeted ubiquitin ligase (STUbL). In proximity-induced therapeutics, RNF4 provides a unique mechanism by recognizing SUMOylated neo-substrates or being directly hijacked by covalent ligands, enabling the precise, signal-dependent clearance of stubborn macromolecular aggregates. |
| Related Disease | Colon adenocarcinoma, breast cancer (elevated levels → poor survival), potentially tumor-promoting |
| Gene ID | 6047 |
| UniProt ID | P78317 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 190 |
| Molecular Weight (kDa) | 23.7 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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