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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human RNF43 protein, Fc Tag |
| Alternative Names | URCC; SSPCS; RNF124 |
| Gene Name | RNF43 |
| Species | Human |
| Introduction | RNF43 is a transmembrane E3 ubiquitin ligase containing a RING finger domain, a protease-associated (PA) domain, and a C-terminal cytoplasmic region. It is frequently mutated in various cancers. |
| Function | RNF43 is a membrane-bound RING-type E3 ligase that natively downregulates Wnt receptors. In proximity-induced pharmacology, RNF43 serves as a premier engine for targeting extracellular and cell-surface transmembrane receptors, driving their internalization, routing them away from recycling paths, and forcing their endosomal/lysosomal destruction. |
| Related Disease | Colorectal cancer (especially MSI-type), pancreatic cancer, gastric cancer, ovarian cancer, liver cancer (loss-of-function mutation → Wnt pathway activation) |
| Gene ID | 54894 |
| UniProt ID | Q68DV8 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 783 |
| Molecular Weight (kDa) | 85.7 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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