Recombinant Human RNF43 protein, Fc Tag (CAT#: PRLP-018)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human RNF43 protein, Fc Tag |
| Alternative Names |
URCC; SSPCS; RNF124 |
| Gene Name |
RNF43 |
| Species |
Human |
| Introduction |
RNF43 is a transmembrane E3 ubiquitin ligase containing a RING finger domain, a protease-associated (PA) domain, and a C-terminal cytoplasmic region. It is frequently mutated in various cancers. |
| Function |
RNF43 is a membrane-bound RING-type E3 ligase that natively downregulates Wnt receptors. In proximity-induced pharmacology, RNF43 serves as a premier engine for targeting extracellular and cell-surface transmembrane receptors, driving their internalization, routing them away from recycling paths, and forcing their endosomal/lysosomal destruction. |
| Related Disease |
Colorectal cancer (especially MSI-type), pancreatic cancer, gastric cancer, ovarian cancer, liver cancer (loss-of-function mutation → Wnt pathway activation) |
| Gene ID |
54894 |
| UniProt ID |
Q68DV8 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
783 |
| Molecular Weight (kDa) |
85.7 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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