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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human SGK3 protein, Fc Tag |
| Alternative Names | CISK, SGK2, SGKL |
| Gene Name | SGK3 |
| Species | Human |
| Introduction | SGK3 is a serine-threonine kinase downstream of the PI3K signaling cascade, sharing high sequence homology with other SGK family members. It harbors a conserved kinase domain and a PX domain that mediates endosomal localization, driving phosphorylation of diverse cellular substrates to support cell survival and proliferation. |
| Function | SGK3 governs cell cycle progression and oncogenic survival signaling. Its well-defined ligand-binding pocket enables engagement by bifunctional chemical agents, which can reroute it toward proteasome-dependent removal, thereby perturbing oncogenic downstream signaling outputs. |
| Related Disease | Breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma |
| Gene ID | 23678 |
| UniProt ID | Q96BR1 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 496 |
| Molecular Weight (kDa) | 57.1 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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