Recombinant Human SGK3 protein, Fc Tag (CAT#: PRLP-071)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human SGK3 protein, Fc Tag |
| Alternative Names |
CISK, SGK2, SGKL |
| Gene Name |
SGK3 |
| Species |
Human |
| Introduction |
SGK3 is a serine-threonine kinase downstream of the PI3K signaling cascade, sharing high sequence homology with other SGK family members. It harbors a conserved kinase domain and a PX domain that mediates endosomal localization, driving phosphorylation of diverse cellular substrates to support cell survival and proliferation. |
| Function |
SGK3 governs cell cycle progression and oncogenic survival signaling. Its well-defined ligand-binding pocket enables engagement by bifunctional chemical agents, which can reroute it toward proteasome-dependent removal, thereby perturbing oncogenic downstream signaling outputs. |
| Related Disease |
Breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma |
| Gene ID |
23678 |
| UniProt ID |
Q96BR1 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
496 |
| Molecular Weight (kDa) |
57.1 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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