Recombinant Human SIAH2 protein, Fc Tag (CAT#: PRLP-017)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human SIAH2 protein, Fc Tag |
| Alternative Names |
hSiah2 |
| Gene Name |
SIAH2 |
| Species |
Human |
| Introduction |
SIAH2 is a paralog of SIAH1 with similar domain architecture: an N-terminal RING domain and a C-terminal substrate-binding domain. It shares high sequence identity with SIAH1 but differs in tissue expression. |
| Function |
SIAH2 operates as a key stress-induced E3 ligase modulating hypoxia and inflammatory signaling. Its integration into chimeric target destruction systems allows for microenvironment-specific degradation kinetics, exploiting tumor hypoxia to selectively activate the destruction of oncogenic neo-substrates tethered by bifunctional bridges. |
| Related Disease |
Breast cancer, HCC, leukemias (tumor-promoting role, correlates with aggressiveness) |
| Gene ID |
6478 |
| UniProt ID |
O43255 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
324 |
| Molecular Weight (kDa) |
34.4 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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