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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human SIAH2 protein, Fc Tag |
| Alternative Names | hSiah2 |
| Gene Name | SIAH2 |
| Species | Human |
| Introduction | SIAH2 is a paralog of SIAH1 with similar domain architecture: an N-terminal RING domain and a C-terminal substrate-binding domain. It shares high sequence identity with SIAH1 but differs in tissue expression. |
| Function | SIAH2 operates as a key stress-induced E3 ligase modulating hypoxia and inflammatory signaling. Its integration into chimeric target destruction systems allows for microenvironment-specific degradation kinetics, exploiting tumor hypoxia to selectively activate the destruction of oncogenic neo-substrates tethered by bifunctional bridges. |
| Related Disease | Breast cancer, HCC, leukemias (tumor-promoting role, correlates with aggressiveness) |
| Gene ID | 6478 |
| UniProt ID | O43255 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 324 |
| Molecular Weight (kDa) | 34.4 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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