Recombinant Human SPOP protein, Fc Tag (CAT#: PRLP-014)
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Datasheets
| Protein Information |
|---|
| Protein Name |
Recombinant Human SPOP protein, Fc Tag |
| Alternative Names |
TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF |
| Gene Name |
SPOP |
| Species |
Human |
| Introduction |
Speckle-type POZ protein (SPOP) is a substrate adaptor of the CUL3-RBX1 E3 ligase, containing an N-terminal BTB domain and a C-terminal MATH domain that binds degron motifs (S/T-rich, Φ-Φ-S/T-S/T). |
| Function |
SPOP acts as a crucial substrate-binding adaptor for the CRL3 ubiquitin ligase complex. Its recruitment in proximity-induced therapeutic platforms leverages its high affinity for specific peptide degron sequences, allowing for the precise, localized polyubiquitination and subsequent proteasomal clearing of targeted pathogenic factors. |
| Related Disease |
Prostate cancer (6-15% of tumors, recurrent mutation), endometrial cancer |
| Gene ID |
8405 |
| UniProt ID |
O43791 |
| Product Specifications |
|---|
| Expression System |
E. coli |
| Expression Length(a.a) |
374 |
| Molecular Weight (kDa) |
42.1 |
| Purity |
0.9 |
| Size |
0.1 mg |
| Physical State |
Aqueous buffer solution |
| Storage |
Stored at -80 °C. Avoid freeze/thaw cycles. |
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