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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human SPOP protein, Fc Tag |
| Alternative Names | TEF2; BTBD32; NSDVS1; NSDVS2; NEDMACE; NEDMIDF |
| Gene Name | SPOP |
| Species | Human |
| Introduction | Speckle-type POZ protein (SPOP) is a substrate adaptor of the CUL3-RBX1 E3 ligase, containing an N-terminal BTB domain and a C-terminal MATH domain that binds degron motifs (S/T-rich, Φ-Φ-S/T-S/T). |
| Function | SPOP acts as a crucial substrate-binding adaptor for the CRL3 ubiquitin ligase complex. Its recruitment in proximity-induced therapeutic platforms leverages its high affinity for specific peptide degron sequences, allowing for the precise, localized polyubiquitination and subsequent proteasomal clearing of targeted pathogenic factors. |
| Related Disease | Prostate cancer (6-15% of tumors, recurrent mutation), endometrial cancer |
| Gene ID | 8405 |
| UniProt ID | O43791 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 374 |
| Molecular Weight (kDa) | 42.1 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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