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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human UBE3A protein, Fc Tag |
| Alternative Names | AS; ANCR; PIX1; E6-AP; HPVE6A; EPVE6AP |
| Gene Name | UBE3A |
| Species | Human |
| Introduction | Ubiquitin protein ligase E3A (UBE3A) is a HECT domain E3 ligase that contains an N-terminal AZUL domain, a C-terminal HECT domain, and regions for binding E6-AP. It is also known as E6AP. |
| Function | UBE3A (E6AP) is the founding member of the HECT-domain E3 ligase family. In targeted clearance platforms, UBE3A offers a distinct mechanistic advantage over traditional RING ligases by directly accepting ubiquitin onto its active-site cysteine before transfer, providing unique ternary complex dynamics and spatial tolerance for large neo-substrates. |
| Related Disease | Angelman syndrome (maternal loss-of-function), autism spectrum disorders (duplication), autism (gain-of-function) |
| Gene ID | 7337 |
| UniProt ID | Q05086 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 875 |
| Molecular Weight (kDa) | 100 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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