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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human VHL protein, Fc Tag |
| Alternative Names | RCA1; VHL1; pVHL; HRCA1 |
| Gene Name | VHL |
| Species | Human |
| Introduction | Von Hippel-Lindau tumor suppressor (VHL) is the substrate recognition subunit of a CUL2-based E3 ubiquitin ligase complex. It contains an elongin binding domain and a β-domain that recognizes hydroxylated proline residues. |
| Function | As a pioneer E3 ligase in proximity-induced degradation, VHL (Von Hippel-Lindau) forms the core of the CRL2-VHL complex. It is highly valued for its predictable structural rigidity, low active-site flexibility, and robust expression across most tissue types. VHL allows bifunctional degraders to form highly stable ternary complexes, driving efficient neo-substrate polyubiquitination and proteasomal clearing. |
| Related Disease | Von Hippel-Lindau disease (retinal hemangiomas, cerebellar/spinal hemangioblastomas, renal cell carcinoma, pheochromocytoma) |
| Gene ID | 7428 |
| UniProt ID | P40337 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 213 |
| Molecular Weight (kDa) | 28.2 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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