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Datasheets
| Protein Information | |
|---|---|
| Protein Name | Recombinant Human ZNRF3 protein, Fc Tag |
| Alternative Names | RNF203; BK747E2.3 |
| Gene Name | ZNRF3 |
| Species | Human |
| Introduction | Zinc and ring finger 3 (ZNRF3) is a related transmembrane E3 ligase with a RING domain and a PA domain. It forms a complex with RNF43 and is also a Wnt pathway regulator. |
| Function | ZNRF3 is a cell-surface E3 ubiquitin ligase that acts alongside RNF43 to control membrane receptor turnover. When hijacked by bispecific or chimeric extracellular degraders, ZNRF3 functions as a powerful surface clearance tool, driving the specific degradation of target transmembrane receptors involved in hyperproliferative pathways. |
| Related Disease | Adrenocortical carcinoma, osteoblastoma (mutation → Wnt pathway activation) |
| Gene ID | 84133 |
| UniProt ID | Q9ULT6 |
| Product Specifications | |
|---|---|
| Expression System | E. coli |
| Expression Length(a.a) | 936 |
| Molecular Weight (kDa) | 89.9 |
| Purity | 0.9 |
| Size | 0.1 mg |
| Physical State | Aqueous buffer solution |
| Storage | Stored at -80 °C. Avoid freeze/thaw cycles. |
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