Target | ARTC2 |
Immunogen | Expression vector encoding full length mouse ARTC2. |
Species Reactivity | Mouse |
Application | BL, Cell Penetration |
Clone | S+16a |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | sp-mNeptune |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | ARTC2, also known as ART2.2, is a 35 kD, GPI-anchored, and cell surface ADP-ribosyltransferase that is highly expressed by regulatory T cells (Tregs) and natural killer T (NKT) cells. ARTC2 is enzymatically active at 4°C. Through the ribosylation of the ion channel P2X7, ARTC2 mediates NAD+-induced cell death (NICD) and the proteolytic shedding of CD27 and CD62L. Blocking the activity ARTC2 with Treg-Protector improves the recovery of Tregs and NKT cells during their isolation from lymphatic and peripheral tissues. |
Target Synonym | Art Rt6; Rt-6; ARTC2; Ly92b; Rt6-2; ART2. 2; Art2b; ADP-ribosyltransferase 2b |
Gene ID | 7011691 |
UniProt ID | O35975 |
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