Anti-HPV 16 E6 (YF96) TCR (HLA-A*0201/TIHDIILECV) Lentivirus Packaging Kit (XS-0622-YF194)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This kit provides a complete lentivirus packaging system to produce anti-E6 (YF96) TCR lentivirus, which enables TCR-T cells generation to target E6. It contains plasmids that express all the viral proteins necessary, and TCR detection reagent, providing a full set of reagents for TCR lentivirus packaging and TCR expression evaluation. The expressed anti-E6 TCR lentiviruses are HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells. These viruses constitutively express the TCR restricted to HLA-A*0201/TIHDIILECV(29-38). TCR detection reagent can be used to detect the positive expression rate of TCR-T cells after lentiviral transduction.

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Description

Target
E6

Components
This kit contains a TCR lentiviral vector, packaging vectors, TCR detection reagent, and 293 cells.
1. A TCR lentiviral vector
• Anti-E6 (YF96) TCR plasmid
2. Three packaging vectors
• LentiArt™ pHelp1
• LentiArt™ pHelp2
• LentiArt™ pHelp3
3. TCR detection reagent
4. 293 cells

Size
10 reactions; 20 reactions; 50 reactions

Storage Conditions
For details of the storage requirements, please see the User Manual for instructions.

Applications
TCR lentivirus packaging; TCR lentivirus transfection; TCR-T cell development; TCR-T cell therapy.

TCR Vector

MHC Allele
HLA-A*0201

Peptide
TIHDIILECV

Epitope
29-38

Vector Name
pCDCAR1

Vector Length
~8kb

Vector Type
Lentiviral vector

TCR Construction
TCR alpha-P2A-TCR beta

Target

Gene Name
E6

Full Name
protein E6*;transforming protein E6

scFv
YF96

Host Species
Human

Target Species
HPV 16

Gene ID
1489078

Uniprot ID
P03126

Target Background
Human papillomavirus (HPV) is a DNA virus from the papillomavirus family that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in keratinocytes of the skin or mucous membranes. Most HPV infections are subclinical and will cause no physical symptoms; however, in some people subclinical infections will become clinical and may cause benign papillomas (such as warts [verrucae] or squamous cell papilloma), premalignant lesions that will drive to cancers of the cervix, vulva, vagina, penis, oropharynx and anus. In particular, HPV16 and HPV18 are known to cause around 70% of cervical cancer cases.

Synonyms
HPV; HPV16; E6

Related Disease
Melanoma

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-HPV 16 E6 (YF96) TCR (HLA-A*0201/TIHDIILECV) Lentivirus Packaging Kit (XS-0622-YF194)

Description

TCR Vector

Target

Customer Reviews and Q&As

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