Canine CAR-T Development Service for Solid Tumor

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Creative Biolabs specializes in canine CAR-T development services for solid tumors to facilitate global customers' projects.

The Prospect of Canine CAR-T Development for Solid Tumor

Canines have a complete immune system and can spontaneously occur solid tumors that are morphologically and genetically similar to humans. Canine CAR-T development will benefit for further study of human solid tumors while providing new understanding and prospects for immunotherapy.

Our Canine CAR-T Development Service for Solid Tumor

Powered by years of experience in the CAR-T field, Creative Biolabs is committed to providing one-stop canine CAR-T development services for solid tumors, which are featured with the following details.

Popular Target Profile to Empower Canine CAR-T Development Service for Solid Tumor

Creative Biolabs offers a variety of popular targets for solid tumor studies, here are several highly effective targets for customers to choose from, including but not limited to:

Canine CAR-T Development Service for Solid Tumor

Outstanding CAR Design & Construction Platform to Enable Canine CAR-T Development for Solid Tumor

CAR design and construction strategy play a crucial role in CAR-T development and facilitate the screening of highly efficient CARTs. Creative Biolabs provides a variety of CAR design and construction platforms to best suit customers' needs.

CAR Design & Construction
Smarter™ Self-destruct CAR Construction	Smarter™ Switch CAR-T Construction	Smarter™ Universal ZipCAR Construction
Smarter™ Orthogonal Dual-Switch CAR Construction	Smarter™ 7 × 19 CAR Construction	Smarter™ Marked CAR Construction
IL-8R-modified CAR Construction	Adnectin-Based CAR Construction	HiCAR Construction

Published Data

Paper Title: Establishment of canine CAR-T cells treatment model for solid tumor immunotherapy development.
Summary: The researchers designed and established 2^nd generation cB7H3-CAR T cells. For in vitro functional evaluation, cB7H3-CAR T cells were highly efficient at killing canine 3D tumor spheroids.
CAR Generation: 2^nd generation;
Cell Type: Canine T cells;
Tumor Model: Canine 3D sarcomas tumor spheroids;
Results:

Fig.1 The 2^nd cB7H3 CAR design. (Zhang, et al., 2020)

Fig.2 In vitro function validation of 2^nd cB7H3 CAR by killing of canine OSA spheroids. (Zhang, et al., 2020)

Frequently Asked Questions

Q1. Solid tumors are different from hematologic malignancies. How does Creative Biolabs design canine CAR-T to enhance the treatment of solid tumors?

A: For the characteristics of solid tumors that are difficult to overcome, we launched a lot of personalized CAR design & construction and provided optimized transfection & delivery methods to enhance the transfection efficiency to achieve the killing effect. For more custom construction strategies, please contact our technical team to meet your needs.

Q2. For canine CAR-T development for solid tumors, which stage is more challenging in the development?

A: In the development, the selection of targets, optimization of scFv sequences, and CAR construction strategies are very important for the whole project, which will affect the subsequent in vitro and in vivo assessment results. And these steps we have a very senior technical team to provide constructive advice for customers.

For more details about our strategies for canine CAR-T development services for solid tumors, please don't hesitate to contact us for more information.

Reference

Zhang, S.; et al. Establishment of canine CAR-T cells treatment model for solid tumor immunotherapy development. J Immunother Cancer. 2020, 8(Suppl 3):A1–A559.