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Anti-SLC34A1 TCR-ABR-3γ (XW-815) CAR Vector (XS-1122-YF3575)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-SLC34A1 TCR-fused Antigen Binding Receptor (TCR-ABR) CAR is constructed for the engineering of T cells to target Human SLC34A1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv (XW-815) of anti-SLC34A1 antibody linked to CD3γ subunit. The vector product was designed for the discovery and development of cellular therapy against Renal cancer. The TCR-ABR can effectively reprogram an intact TCR complex to recognize tumor surface antigens. TCR-ABR-T cells are shown to engage the signaling capacity of the entire TCR complex in an HLA-independent manner.

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Details

  • Target
  • SLC34A1
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Renal cancer
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-CD3γ
  • Discription of Signaling Cassetes
  • The scFv used to generate CAR-T cells or single domain antibodies can be fused to the extracellular N-termini of TCRα, TCRβ, CD3γ, CD3δ, or CD3ε subunits, resulting in the activation of target-specific TCR-ABR-T cells. TCR-ABR-T cells have been shown to use the entire TCR complex's signaling capacity in an HLA-independent manner.

Target

  • Clone
  • XW-815
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Sodium-dependent phosphate transport protein 2A
  • Synonyms
  • SLC34A1; NPT2; NPTIIa; solute carrier family 34 member 1; NaPi-2a; HCINF2; SLC17A2; SLC11; NAPI-3; FRTS2; NPHLOP1
  • Introduction
  • This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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